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Trading list news update - Oct 14: TGTX - TG Therapeutics

TG Therapeutics announces updated data from multiple sclerosis trials

TG Therapeutics announced data presentations, including additional analyses from two global, active-controlled, Phase 3 studies, called ULTIMATE I & II, evaluating ublituximab, the company's investigational novel, glycoengineered anti-CD20 monoclonal antibody, compared to teriflunomide, in patients with relapsing forms of multiple sclerosis. As previously reported, both studies met their primary endpoint with ublituximab treatment demonstrating a statistically significant reduction in annualized relapse rate over a 96-week period. In ULTIMATE I, treatment with ublituximab resulted in an annualized relapse rate of 0.076 compared to 0.188 for teriflunomide, representing a relative reduction of approximately 60%. In ULTIMATE II, treatment with ublituximab resulted in an ARR of 0.091 compared to 0.178 for teriflunomide, representing a relative reduction of approximately 50%. A post-hoc analysis of the slopes from week 24 - week 96 showed there was no difference in the brain volume decline between the arms in ULTIMATE I and the rate of brain volume decline was lower for ublituximab in ULTIMATE II. In a prespecified analysis, ublituximab treatment was associated with significant improvement in Multiple Sclerosis Functional Composite score as compared to teriflunomide in both ULTIMATE I and II. "The data further elucidate the potential benefits of ublituximab treatment especially on the tertiary endpoint of improvement in MSFC score, a detailed review of which is the subject of a late breaking e-poster.. We look forward to today's event and hope you all can join us and hear from the key opinion leaders," said TG CEO Michael Weiss.


Our Take: "Our top pick! If you don't own this, but some now and put it away. This MS drug is looking great. Just a matter of time before this company gets bought out."


$TGTX, TG Therapeutics, Inc. / H1



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